Single-cell Nanobiopsy of living cells

We developed a single-cell nanobiopsy platform based on scanning ion conductance microscopy (SICM) for continuous sampling of intracellular content from individual cells. The nanobiopsy platform uses electrowetting within a nanopipette to extract cellular material from living cells with minimal disruption of the cellular milieu. We used this technology to study mitochondrial heterogeneity within a single living cell.

The full paper can be found here

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